Protection circuits and methods for protecting an integrated circuit against an over-limit electrical condition are provided. One example includes a snapback circuit having at least a portion formed in an isolated doped well region and configured to switch to a low impedance state in response to an input exceeding a trigger condition and further having a control circuit coupled to a reference voltage and further coupled to the isolated doped well region and the portion of the snapback circuit formed in the doped well region. The control circuit includes an impedance adjustable in response to a control signal and configured to adjust an isolated doped well impedance in which at least a portion of the snapback circuit is formed relative to the reference voltage. A modulated trigger and hold condition tot the snapback circuit can be set according to a control signal adjusting an electrical impedance of the control circuit.