Exemplary multi-screen casting systems and methods are disclosed. For example, systems and methods for casting a graphical user interface display of a mobile device to a display screen associated with a set-top-box device are disclosed. An exemplary method includes a multi-screen casting system establishing a multi-screen display relationship between a mobile device and a set-top-box device, identifying data associated with a graphical user interface display of the mobile device, and transmitting the identified data associated with the graphical user interface display of the mobile device to the set-top-box device for display by a display device associated with the set-top-box device. Corresponding methods and systems are also disclosed.