- 专利标题： Activators of human pyruvate kinase
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申请号： US15076258申请日： 2016-03-21
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公开(公告)号： US09707230B2公开(公告)日： 2017-07-18
- 发明人: Craig J. Thomas , Douglas S. Auld , James Inglese , Amanda P. Skoumbourdis , Jian-Kang Jiang , Matthew B. Boxer
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D495/14 ; A61K31/5025 ; A61K31/445 ; A61K31/495 ; C07D295/26 ; C07D319/18
摘要：
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
公开/授权文献
- US20160199370A1 ACTIVATORS OF HUMAN PYRUVATE KINASE 公开/授权日：2016-07-14
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