A peak current protection circuit includes a current sensing circuit configured to sense an operating current of a DC-DC converter, and an over-current detector operably coupled with the current sensing circuit. The over-current detector is configured to generate an over-current detect signal at a peak current limit that is that is independent of a voltage level of an output signal of the DC-DC converter. A method for providing over-current protection for a DC-DC converter includes sensing an operating current of a DC-DC converter at a first input of a comparator, sensing a reference current at a second input of the comparator, comparing the first input with the second input, and generating an over-current detect signal in response to the comparison such that a peak current limit for the DC-DC converter is independent of a voltage level of an output signal of the DC-DC converter.