The present invention relates to a method and device for inter-cluster cooperative communication in a mobile communication system. A central unit operating method for inter-cluster cooperative communication in a mobile communication system comprises processes comprising: a process of receiving channel data from serving sectors in a serving cluster; a process of respectively receiving the magnitude of change of a target function for scheduling depending on whether the serving sector is blank, from neighboring sectors in neighboring clusters of the serving cluster; and a process of determining the blank pattern of the serving cluster, by using the channel data received from the serving sectors, and the magnitude of change of the target function received from the neighboring sectors in neighboring clusters.