An apparatus and method for performing uplink scheduling in a Multiple-Input Multiple-Output (MIMO) system are provided. The method includes selecting User Equipments (UEs) as members of at least one user set for simultaneous transmission from among UEs from which channel information is received, using the channel information, and generating a power control value for each of the at least one user set and transmitting the power control value to UEs of the user set. The at least one user set includes a second user set including UEs selected according to interference that the UEs cause to a first user set from among remaining UEs unselected for the first user set, the first user set including UEs selected in a descending order of reception power from among the UEs from which the channel information is received.