- 专利标题: N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals
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申请号: US14775620申请日: 2014-03-12
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公开(公告)号: US09718825B2公开(公告)日: 2017-08-01
- 发明人: Marc Nazare , Nis Halland , Friedemann Schmidt , Heinz-Werner Kleemann , Tilo Weiss , Joachim Saas , Carsten Struebing
- 申请人: SANOFI
- 申请人地址: FR Paris
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: FR Paris
- 代理机构: Morrison & Foerster LLP
- 优先权: EP13305283 20130313
- 国际申请: PCT/EP2014/054770 WO 20140312
- 国际公布: WO2014/140065 WO 20140918
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D487/04 ; A61K31/4162
摘要:
The present invention relates to N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides of the formula I, wherein Ar, n, X, Z, R1, R2 and R3 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activity, specifically the activity of serum and glucocorticoid regulated kinase (SGK), in particular of serum and glucocorticoid regulated kinase isoform 1 (SGK-1, SGK1), and are suitable for the treatment of diseases in which SGK activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
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