In various embodiments, an end effector for use with a surgical instrument is disclosed comprising a linear portion, a first jaw, and a second jaw moveable relative to the first jaw, wherein one of the first jaw and the second jaw comprises a plurality of staple cavities arranged in a plurality of curved staple cavity rows, and wherein the curved staple cavity rows curve in a first direction. The end effector further comprises a curved path extending between two curved staple cavity rows of the plurality of curved staple cavity rows, wherein the curved path curves in the first direction, and a drive assembly extending along at least a portion of the linear portion, wherein the drive assembly comprises a cutting element structured to travel along the curved path, wherein the cutting element comprises a distal pre-biased cutting edge structured to lead the cutting element in the first direction.