An end effector for use by a surgeon to staple an anatomical structure of a patient during a surgical procedure includes an anvil and a cartridge. Each of the anvil and the cartridge has a face that is positionable on the anatomical structure. The anvil is coupled the cartridge at first and second ends. The anvil is movable relative to the cartridge to define a first gap between the faces at the first ends that is less than a second gap between the faces at the second ends. A stapling device includes the end effector coupled to a manipulator via a shaft. The manipulator is accessible to the surgeon. The surgeon uses a clamping mechanism to selectively move the anvil and the cartridge to clamp the anatomical structure.