Invention Grant
- Patent Title: Stabilized trimeric HIV-1 GP41 fusion inhibitor polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif
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Application No.: US14796725Application Date: 2015-07-10
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Publication No.: US09724383B2Publication Date: 2017-08-08
- Inventor: Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
- Applicant: New York Blood Center, Inc.
- Applicant Address: US NY New York
- Assignee: New York Blood Center, Inc.
- Current Assignee: New York Blood Center, Inc.
- Current Assignee Address: US NY New York
- Agency: K&L Gates LLP
- Agent Louis C. Cullman; Michelle Glasky Bergman
- Main IPC: C07K14/05
- IPC: C07K14/05 ; A61K38/16 ; C07K14/005 ; C12N7/00 ; A61K38/00
Abstract:
Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
Public/Granted literature
- US20150306174A1 Trimeric HIV Fusion Inhibitors for Treating or Preventing HIV Infection Public/Granted day:2015-10-29
Information query
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