- Patent Title: Lysine oligomer derivative and cartilage tissue marker made thereof
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Application No.: US14383976Application Date: 2013-03-13
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Publication No.: US09724434B2Publication Date: 2017-08-08
- Inventor: Toshitaka Oohashi , Hiroki Kakuta
- Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
- Applicant Address: JP Okayama
- Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
- Current Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
- Current Assignee Address: JP Okayama
- Agency: Buchanan, Ingersoll & Rooney PC
- Priority: JP2012-055511 20120313
- International Application: PCT/JP2013/056974 WO 20130313
- International Announcement: WO2013/137302 WO 20130919
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C07K7/02 ; A61K49/04 ; C07K5/02 ; A61K47/48 ; A61K49/08 ; A61K51/04

Abstract:
There is provided a lysine oligomer derivative, wherein an ε-amino group and a carboxyl group of lysines are linked via a peptide bond, and a group capable of generating or absorbing electromagnetic wave is bonded to a C-terminal carboxyl group, an N-terminal amino group and/or an α-amino group. This lysine oligomer derivative has the characteristic of specifically accumulating in the cartilage matrix and can generate or absorb an electromagnetic wave, and is, therefore, useful as a cartilage tissue marker.
Public/Granted literature
- US20150080551A1 LYSINE OLIGOMER DERIVATIVE AND CARTILAGE TISSUE MARKER MADE THEREOF Public/Granted day:2015-03-19
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