A system and method according to various embodiments combines three separate technologies to form a unique lighting system with enhanced antimicrobial properties and air cleaning capabilities. The combination of the three technologies also produces a lighting system that extends the required maintenance period for lighting fixtures. The first technology is based on anatase type TiO2. The second and third technologies are based on the use of micro-sized surface structures to generate light scattering effects and, at the same time, reduce bacterial colonization and inhibit bacterial migration even during the absence of light or in dark environments.