The invention relates to a drug delivery device for setting and dispensing a dose of a drug, comprising: a support body having a first end defining a first opening and a second end defining a second opening, the support body configured to retain a syringe barrel sealed by a stopper slidably disposed therein along an axial direction and adapted to have an integrated needle or to be coupled with a needle assembly, a needle shield adapted to be coupled to one of the ends of the support body, slidably disposed thereon and keyed to the support body for preventing relative rotation, wherein at least one guiding track is defined on the support body and at least one retaining clip arranged on the needle shield is deflectable by the guiding track, wherein the guiding track is configured such that the retaining clip follows a first path when the needle shield is depressed from an extended position to a retracted position for needle extension and that the retaining clip follows a different second path when the needle shield is subsequently extended, wherein a non-return catch is arranged for catching the retaining clip at the end of the second path.