A spiral wound filtration assembly including: i) a pressure vessel comprising a feed port, concentrate port and permeate port; ii) at least one spiral wound membrane module comprising at least one membrane envelop wound around a permeate tube which forms a permeate pathway to the permeate port; and iii) a bioreactor having a cylindrical outer periphery extending along an axis (Y) from a first end to a second end, an inlet located near the first end, and an outlet located near the second end; wherein the spiral wound membrane module and bioreactor are serially arranged within the pressure vessel.