Invention Grant
- Patent Title: Nitroso compounds as nitroxyl donors and methods of use thereof
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Application No.: US14927994Application Date: 2015-10-30
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Publication No.: US09725402B2Publication Date: 2017-08-08
- Inventor: Lisa Marie Frost , Stephen Martin Courtney , Frederick Arthur Brookfield , Vincent Jacob Kalish
- Applicant: Cardioxyl Pharmaceuticals, Inc.
- Applicant Address: US NC Chapel Hill
- Assignee: Cardioxyl Pharmaceuticals, Inc.
- Current Assignee: Cardioxyl Pharmaceuticals, Inc.
- Current Assignee Address: US NC Chapel Hill
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- Main IPC: C07C207/04
- IPC: C07C207/04 ; C07C207/00 ; C07D309/14 ; C07D407/12 ; C07D211/44 ; C07D211/58 ; C07D333/42 ; C07D405/12 ; C07D405/14 ; C07D451/10 ; C07F9/117 ; C07F9/58 ; C07C255/19 ; C07D309/10 ; C07F9/59
Abstract:
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
Public/Granted literature
- US20160052862A1 NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF Public/Granted day:2016-02-25
Information query
