Invention Grant
- Patent Title: N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
-
Application No.: US15286145Application Date: 2016-10-05
-
Publication No.: US09725410B2Publication Date: 2017-08-08
- Inventor: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- Applicant: Cardioxyl Pharmaceuticals, Inc. , The Johns Hopkins University
- Applicant Address: US MD Baltimore US NC Chapel Hill
- Assignee: The Johns Hopkins University,Cardioxyl Pharmaceuticals Inc.
- Current Assignee: The Johns Hopkins University,Cardioxyl Pharmaceuticals Inc.
- Current Assignee Address: US MD Baltimore US NC Chapel Hill
- Agency: Dechert LLP
- Main IPC: C07C311/00
- IPC: C07C311/00 ; C07C317/00 ; C07C323/00 ; C07D213/74 ; C07D231/00 ; C07D261/00 ; A61K31/00 ; C07C311/48 ; C07D261/10 ; C07D263/58 ; C07D285/125 ; C07D295/096 ; C07D307/82 ; C07D333/62 ; C07C317/14 ; C07C323/67 ; C07D309/12 ; C07D317/14 ; C07D231/18 ; C07D333/34
Abstract:
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
Public/Granted literature
- US20170022154A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS Public/Granted day:2017-01-26
Information query
