Invention Grant
- Patent Title: Quinazoline derivative and preparation method therefor
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Application No.: US15024472Application Date: 2014-09-28
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Publication No.: US09725439B2Publication Date: 2017-08-08
- Inventor: Dengming Xiao , Yan Zhu , Yuandong Hu , Huting Wang , Jijun Li , Yong Peng , Hui Zhang , Hong Luo , Fansheng Kong , Yongxin Han
- Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. , CENTAURUS BIOPHARMA CO., LTD. , LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Jiangsu CN Beijing CN Jiangsu
- Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.,CENTAURUS BIOPHARMA CO., LTD.,LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
- Current Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.,CENTAURUS BIOPHARMA CO., LTD.,LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Jiangsu CN Beijing CN Jiangsu
- Agency: Fish & Richardson P.C.
- Priority: CN201310452885 20130928
- International Application: PCT/CN2014/087633 WO 20140928
- International Announcement: WO2015/043515 WO 20150402
- Main IPC: C07D403/12
- IPC: C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D401/12
Abstract:
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.
Public/Granted literature
- US20160214964A1 QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR Public/Granted day:2016-07-28
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