Invention Grant
- Patent Title: Neprilysin inhibitors
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Application No.: US15270187Application Date: 2016-09-20
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Publication No.: US09725448B2Publication Date: 2017-08-08
- Inventor: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K45/06 ; A61K31/42 ; C07D239/34 ; A61K31/505 ; C07D231/14 ; A61K31/415 ; C07D231/20 ; C07D249/04 ; A61K31/4192 ; C07D249/10 ; A61K31/4196 ; C07D249/18 ; A61K31/437 ; C07D261/18 ; C07D239/36 ; C07D257/04 ; C07D261/12 ; C07D403/04 ; C07C271/22 ; C07C243/28 ; C07D487/04

Abstract:
In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20170066764A1 NEPRILYSIN INHIBITORS Public/Granted day:2017-03-09
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