Invention Grant
- Patent Title: Substituted indoles and pyrroles as RIP kinase inhibitors
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Application No.: US14214360Application Date: 2014-03-14
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Publication No.: US09725452B2Publication Date: 2017-08-08
- Inventor: Junying Yuan , Alexei Degterev , Gregory D. Cuny
- Applicant: President and Fellows of Harvard College , Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Tufts University , University of Houston
- Applicant Address: US MA Cambridge CN Shanghai US MA Boston US TX Houston
- Assignee: Presidents and Fellows of Harvard College,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Tufts University,University of Houston
- Current Assignee: Presidents and Fellows of Harvard College,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Tufts University,University of Houston
- Current Assignee Address: US MA Cambridge CN Shanghai US MA Boston US TX Houston
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda H. Jarrell; Nishat A. Shaikh
- Main IPC: A61K31/4025
- IPC: A61K31/4025 ; A61K31/404 ; C07D207/30 ; C07D209/04 ; C07D487/04 ; C07D401/14 ; C07D471/04
Abstract:
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.
Public/Granted literature
- US20140323489A1 HYBRID NECROPTOSIS INHIBITORS Public/Granted day:2014-10-30
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