Invention Grant
- Patent Title: Substituted heterocyclic compounds as CRAC modulators
-
Application No.: US14899719Application Date: 2014-06-20
-
Publication No.: US09725463B2Publication Date: 2017-08-08
- Inventor: Nageswara Rao Irlapati , Nilesh Raghunath Khedkar , Ravindra Babanrao Jape , Rahul Shripad Nandurdikar , Zubair Abdul Wajid Shaikh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
- Applicant: LUPIN LIMITED
- Applicant Address: IN Mumbai
- Assignee: LUPIN LIMITED
- Current Assignee: LUPIN LIMITED
- Current Assignee Address: IN Mumbai
- Agency: Merchant & Gould P.C.
- Priority: IN2105/MUM/2013 20130621; IN917/MUM/2014 20140320
- International Application: PCT/IB2014/062482 WO 20140620
- International Announcement: WO2014/203217 WO 20141224
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D263/58 ; C07D265/36 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; A61K31/5377

Abstract:
The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators. wherein, ring D is Formula (a) or Formula (b): A and B, which may be same or different, are independently CR3 or N; Y is CR3 or N; L is selected from —NR2C(O)—, —C(O)NR2— and —NR2CRaRb—; Ra and Rb are independently hydrogen, halogen or substituted or unsubstituted alkyl; ring E is selected from the Formula (i) to (vii).
Public/Granted literature
- US20160145268A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS CRAC MODULATORS Public/Granted day:2016-05-26
Information query