Invention Grant
- Patent Title: Arsenoplatin anti-cancer agents
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Application No.: US15291274Application Date: 2016-10-12
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Publication No.: US09725475B2Publication Date: 2017-08-08
- Inventor: Denana U. Miodragovic , Thomas V. O'Halloran
- Applicant: Northwestern University
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Klintworth & Rozenblat IP LLC
- Main IPC: C07F9/70
- IPC: C07F9/70 ; C07F15/00 ; A61K31/282 ; A61K31/285 ; A61K31/29 ; A61K31/295 ; C07F15/04

Abstract:
Disclosed herein are conjugates that include a ligand, and a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base; Y1 and Y2 are independently selected from —OR3, —OR4, —SR3 and —SR4, wherein R1 and R2 are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl; and R3 and R4 are independently selected from hydrogen, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl.
Public/Granted literature
- US20170037070A1 ARSENOPLATIN ANTI-CANCER AGENTS Public/Granted day:2017-02-09
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