Invention Grant
- Patent Title: 5′-end derivatives
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Application No.: US13696796Application Date: 2011-04-22
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Publication No.: US09725479B2Publication Date: 2017-08-08
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , Ivan Zlatev , Eric E. Swayze , Thazha P. Prakash , Walter F. Lima
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , Ivan Zlatev , Eric E. Swayze , Thazha P. Prakash , Walter F. Lima
- Applicant Address: US CA Carlsbad US MA Cambridge
- Assignee: Ionis Pharmaceuticals, Inc.,Alaylam Pharmacueuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.,Alaylam Pharmacueuticals, Inc.
- Current Assignee Address: US CA Carlsbad US MA Cambridge
- Agency: Ionis Patent Department
- International Application: PCT/US2011/033592 WO 20110422
- International Announcement: WO2011/133871 WO 20111027
- Main IPC: C07H17/02
- IPC: C07H17/02 ; C07H19/067 ; C07H21/02 ; C12N15/113
Abstract:
The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Public/Granted literature
- US20130323836A1 5'-END DERIVATIVES Public/Granted day:2013-12-05
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