Invention Grant
- Patent Title: 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
-
Application No.: US14785175Application Date: 2014-04-17
-
Publication No.: US09725481B2Publication Date: 2017-08-08
- Inventor: Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis
- Applicant: SAGE THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: Sage Therapeutics, Inc.
- Current Assignee: Sage Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Goodwin Procter LLP
- Priority: WOPCT/CN2013/074325 20130417
- International Application: PCT/CN2014/075585 WO 20140417
- International Announcement: WO2014/169831 WO 20141023
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J7/00 ; C07J17/00 ; C07J33/00 ; C07J9/00 ; C07J1/00 ; C07J21/00 ; C07J3/00 ; C07J41/00 ; C07J13/00

Abstract:
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein, , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5-to6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
Public/Granted literature
- US20160083417A1 19-NOR C3, 3-DISUBSTITUTED C21-C-BOUND HETEROARYL STEROIDS AND METHODS OF USE THEREOF Public/Granted day:2016-03-24
Information query