Invention Grant
- Patent Title: Peptide-hinge-free flexible antibody-like molecule
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Application No.: US14569070Application Date: 2014-12-12
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Publication No.: US09725503B2Publication Date: 2017-08-08
- Inventor: Daniel J. Capon
- Applicant: Daniel J. Capon
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C07K14/47
- IPC: C07K14/47 ; C07K7/06 ; C07K7/08 ; C07K16/18

Abstract:
The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part comprising: a group having a nonpeptide hinge part represented by a general formula (I): XY-Asp-Lys-Thr-His-Thr (SEQ ID No. 1)—wherein X represents an amino acid or a peptide composed of 2 to 50 amino acid residues, and Y represents for a group having an alkyleneoxide; and an antibody Fc fragment bound to the group having a nonpeptide hinge part.
Public/Granted literature
- US20150183858A1 PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE Public/Granted day:2015-07-02
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