Invention Grant
- Patent Title: Levels of BCMA protein expression on B cells and use in methods of treating systemic lupus erythematosus
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Application No.: US14192911Application Date: 2014-02-28
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Publication No.: US09725506B2Publication Date: 2017-08-08
- Inventor: Stacey R. Dillon , Jane A. Gross , Keith B. Elkon
- Applicant: ZymoGenetics, Inc. , University of Washington
- Applicant Address: US WA Seattle US WA Seattle
- Assignee: ZYMOGENETICS, INC.,UNIVERSITY OF WASHINTON
- Current Assignee: ZYMOGENETICS, INC.,UNIVERSITY OF WASHINTON
- Current Assignee Address: US WA Seattle US WA Seattle
- Agency: Womble Carlyle Sandridge & Rice LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/24 ; G01N33/50 ; C07K14/705 ; G01N33/564
Abstract:
The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs.
Public/Granted literature
- US20140220014A1 LEVELS OF BCMA PROTEIN EXPRESSION ON B CELLS AND USE IN DIAGNOSTIC METHODS Public/Granted day:2014-08-07
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