An example method for collection and analysis of particles from a particle generating source enclosed within an enclosure having an inlet and an outlet is described. The method includes supplying filtered air into the enclosure through the inlet, extracting, with a vacuum source, an aerosol stream including particles from the particle generating source through the outlet, directing the aerosol stream from the outlet of the enclosure to the vacuum source via a sampling tower. The sampling tower includes at least one nozzle for sampling the aerosol stream. The method includes detecting, with a detection instrument coupled to the nozzle, at least one characteristic of the particles in the aerosol stream, and outputting data concerning the detected characteristic of the particles in the aerosol stream to a computing device.