A hand control device for controlling a peripheral system is disclosed. The hand control device can include a handle configured to be grasped by a user. The handle can comprise a body portion to be supported against a palm of the user. The hand control device can also include a finger control supported about the handle and comprising a rotatable joint to facilitate control based on flexion/extension of an index finger of the user. In addition, the hand control device can include a thumb control supported about the handle and comprising first and second rotatable joints to facilitate control based on flexion/extension and abduction/adduction of a thumb of the user.