A chassis input/output (I/O) module adapted for use in a front region of a mass storage chassis assembly is provided. The chassis I/O module in one example includes an I/O module shell, a main I/O connector externally available on the I/O module shell, a plurality of sub-assembly connectors externally available on the I/O module shell, one or more power supply modules, and an interface module electrically coupled to the main I/O connector, the plurality of sub-assembly connectors, and the one or more power supply modules, with the interface module configured to regulate operations of one or more mass storage sub-assemblies installed in the mass storage chassis assembly, regulate provision of electrical power from the one or more power supply modules to the one or more mass storage sub-assemblies, and facilitate exchange of electrical signals between the one or more mass storage sub-assemblies and the main I/O connector.