An error detection system detects errors in data packets stored in a memory. A read signature generation circuit generates a read signature of a first data packet. A write signature generation circuit generates a write signature of a second data packet. When a trigger generation circuit generates a trigger signal, a first latching circuit stores a write address as a latch write address and a second latch stores the write signature as a latch write signature. A first synchronization and comparison circuit generates a comparison signal based on the latched write address and a read address. A second synchronization and comparison circuit generates a fault signal based on the comparison signal, the latched write signature, and the read signature.