Systems and methods presented herein provide for region lock management in an expander. In one embodiment, an expander, being operable to link a plurality of initiators to a plurality of Redundant Array of Independent Disks logical volumes, includes a plurality of physical transceivers, each being operable to link the logical volumes to the initiators, and a region lock manager operable to receive a request from a first of the initiators to lock a region of the logical volumes for an input/output operation by the first initiator. The region lock manager is also operable to determine if the requested region is unlocked, to lock the requested region from the remaining initiators to allow the input/output operation of the first initiator after determining the requested region is unlocked, and to unlock the requested region after the input/output operation of the first initiator is complete.