A method, computer program product, and system to implement access control from a master device to a slave device over an inter-integrated circuit (I2C) interface are described. The method includes generating, using a processor, a control block defining the access control to the slave device over the I2C interface. The generating the control block is performed by the trusted code layer and the generating the control block is prohibited by the user-modifiable code layer. The method also includes controlling a command over the I2C interface to the slave device based on a generated command from the trusted code layer and the user-modifiable code layer in accordance with the control block.