The present disclosure provides a display drive method for driving a 3D display device. The method comprises: dividing a first view and a second view to be displayed into a plurality of theoretical pixel units, respectively, and determining a respective gray value corresponding to a color of each type of subpixels in original display information corresponding to each theoretical pixel unit; and for each subpixel of each view, determining brightness of the subpixel based on respective gray values corresponding to the color of the subpixel in the original display information corresponding to respective theoretical pixel units which are covered by a rectangular sampling region of the subpixel and belong to the view. The present disclosure further provides a display drive apparatus and a method and apparatus for generating a sampling region.