The present invention provides an AMOLED pixel driving circuit and a pixel driving method. The AMOLED pixel driving circuit utilizes the 4T2C structure, comprising a first, a second, a third, a fourth thin film transistors (T1, T2, T3, T4), a first, a second capacitor (C1, C2) and an organic light emitting diode (OLED) with introducing a first, a second global signals (Vselx, Vsely) and a reference voltage (Vref); by providing the reference voltage (Vref) to the first node (a) via the third thin film transistor (T3), the data signal voltage (Vdata) can be simplified to diminish the complexity of the data signal voltage (Vdata). The process of writing the data signal voltage (Vdata) into the first thin film transistor T1, i.e. the driving the thin film transistor is separated from the reset stage (Reset) and the threshold voltage detection stage (Vth sensing) with the fourth thin film transistor (T4). Thus, the reset time and the compensation time can be increased to effectively compensate the threshold voltage changes of the drive thin film transistor and the display brightness of the AMOLED becomes more even to raise the display quality.