A self-sealing flow frame is provided having a first frame component and a second frame component. Each frame component is provided with a tongue-and-groove configuration that when assembled forms a tessellation engagement, which creates the seal. When each frame component is assembled into a flow frame, with the inner surfaces facing towards each other, the tongue-and-groove arrangements create a seal profile that circumscribe constituent parts of a device within which the self-sealing flow frame is being employed. As the frame components are compressively secured and fastened together, a tessellation engagement of the seal profile forms the fluid seal. Fluids of the device are prevented from exfiltrating the device, and are contained within the self-sealing flow frame by the fluid seal.