System and method embodiments are provided for high efficiency wireless communications. In an embodiment, a method in a network component for transmitting a frame of two different fast Fourier transform (FFT) sizes includes generating a frame, wherein the frame comprises orthogonal frequency-division multiplexing (OFDM) symbols in two different FFT sizes, wherein the frame comprises a first portion and a second portion, wherein the first portion comprises a first FFT size and the second portion comprises a second FFT size; and transmitting the frame during a single transmission opportunity.