- 专利标题: Nutritional compositions for promoting gut barrier function and ameliorating visceral pain
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申请号: US14934559申请日: 2015-11-06
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公开(公告)号: US09730969B2公开(公告)日: 2017-08-15
- 发明人: Yan Zhong , Teartse Tim Lambers , Gabriele Gross , Sarmauli Manurung , Eric A. F. van Tol , Rosaline Waworuntu
- 申请人: Mead Johnson Nutrition Company
- 代理机构: OspreyIP, pllc
- 代理商 James R. Cartiglia; Bethany J. Whelan
- 主分类号: A61K35/747
- IPC分类号: A61K35/747 ; A23L1/29 ; A23L1/30
摘要:
The present disclosure is directed to methods for i) promoting gut regeneration, ii) promoting gut maturation and/or adaptation, iii) supporting gut barrier resistance and/or iv) protecting gut barrier function in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation derived from a late-exponential growth phase of a probiotic batch-cultivation process, such as Lactobacillus rhamnosus GG (LGG). The present methods advantageously provide the gut-protection benefits of LGG soluble mediators without introducing live bacterial culture to individuals with impaired gut barrier function. In some embodiments, the pediatric subject has impaired gut barrier function and/or short bowel syndrome. The present disclosure in other embodiments, directed methods for reducing visceral pain in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation from a late-exponential growth phase of a probiotic batch-cultivation process, such as LGG.