发明授权
- 专利标题： Compounds and methods for activating the apoptotic arm of the unfolded protein response
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申请号： US14408736申请日： 2013-06-18
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公开(公告)号： US09732067B2公开(公告)日： 2017-08-15
- 发明人: Jennifer E. Golden , Jeffrey Aube , Daniel P. Flaherty , Andrew M. Fribley , Randal J. Kaufman , Thomas D. Y. Chung , Anthony B. Pinkerton , Michael Pablo Hedrick
- 申请人： University of Kansas , The Regents of the University of Michigan , Wayne State University , Sanford-Burnham Medical Research Institute
- 申请人地址： US KS Lawrence US CA La Jolla US MI Ann Arbor US MI Detroit
- 专利权人： University of Kansas,Sanford-Burnham Medical Research Institute,The Regents of the University of Michigan,Wayne State University
- 当前专利权人： University of Kansas,Sanford-Burnham Medical Research Institute,The Regents of the University of Michigan,Wayne State University
- 当前专利权人地址： US KS Lawrence US CA La Jolla US MI Ann Arbor US MI Detroit
- 代理机构： Licata & Tyrrell P.C.
- 国际申请： PCT/US2013/046290 WO 20130618
- 国际公布： WO2013/192165 WO 20131227
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07C303/36 ; A61K31/4525 ; C07D307/71 ; A61K31/496 ; A61K31/5377 ; A61K45/06
摘要：
N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
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