发明授权
- 专利标题： Method for crystallization of TRX-TXNIP complex mutein and 3D structure thereof
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申请号： US14414370申请日： 2013-07-12
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公开(公告)号： US09732126B2公开(公告)日： 2017-08-15
- 发明人: Myung Hee Kim , Jung Won Hwang , Tae Kwang Oh
- 申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： KR10-2012-0076310 20120712
- 国际申请： PCT/KR2013/006286 WO 20130712
- 国际公布： WO2014/011003 WO 20140116
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; G01N33/574 ; C12N9/02 ; G01N33/53
摘要：
The present invention relates to a modified TXNIP protein, a method for preparing the modified TXNIP protein, a polynucleotide encoding the modified protein, an expression vector including the polynucleotide, a transformant introduced with the expression vector, a method for crystallizing a modified TRX-TXNIP complex using the modified TXNIP protein, and a method for screening a substance regulating interaction between TRX and TXNIP, an inhibitor of TRX activity, or a substance regulating TXNIP function.