An anti-reflection coat includes an intermediate layer and a low refractive index layer sequentially stacked on a substrate, and preventing the reflection of incident light by optical interference effect, wherein the low refractive index layer is a film formed on the surface of the intermediate layer by a wet film formation method using a coating liquid including layer-constituting raw materials which includes hollow silica particles adhering each other with a binder, and the intermediate layer is a layer mainly composed of an organometallic compound which adheres well to the binder and having wettability to the coating liquid; and provides an optical device including the anti-reflection coat.