Invention Grant
- Patent Title: HIV protease inhibitors
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Application No.: US15104782Application Date: 2014-12-17
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Publication No.: US09737545B2Publication Date: 2017-08-22
- Inventor: John A. McCauley , Christian Beaulieu , David Jonathan Bennett , Christopher J. Bungard , Sheldon Crane , Thomas J. Greshock , Katharine M. Holloway , Helen Juteau , Daniel McKay , Carmela Molinaro , Oscar Miguel Moradei , Christian Nadeau , Daniel Simard , Satyanarayana Tummanapalli , Vouy Linh Truong , Karine M. Villeneuve , Peter D. Williams
- Applicant: MERCK SHARP & DOHME CORP. , MERCK CANADA INC.
- Applicant Address: US NJ Rahway CA Kirkland, Quebec
- Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee Address: US NJ Rahway CA Kirkland, Quebec
- Agent Carol S. Quagliato; Catherine D. Fitch
- International Application: PCT/US2014/070725 WO 20141217
- International Announcement: WO2015/095265 WO 20150625
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D417/04 ; A61K45/06 ; C07D487/04 ; C07D471/04 ; C07D413/04 ; C07D265/30 ; C07D413/14
Abstract:
The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Public/Granted literature
- US20160296527A1 HIV PROTEASE INHIBITORS Public/Granted day:2016-10-13
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