A method for adaptively-tuned digital self-interference cancellation comprises receiving a digital transmit signal; receiving a transform configuration; generating a set of signal components from the digital transmit signal; transforming the set of signal components into a digital self-interference cancellation signal according to the transform configuration; combining the digital self-interference cancellation signal with a receive signal to form a digital residue signal; detecting a trigger; in response to detecting the trigger: computing a ratio of the digital residue signal to the digital transmit signal; converting the ratio to the frequency-domain to form a frequency-domain-converted ratio; computing a frequency-domain self-interference channel between the transmitter and the receiver based on the frequency-domain-converted ratio; computing an inverse discrete Fourier transform matrix based on a portion of the discrete Fourier transform matrix; converting the frequency-domain self-interference channel to form a time-domain self-interference channel; and updating the transform configuration based on the time-domain self-interference channel.