A system and method for calibrating a digital imaging device for color correction is disclosed. The method comprises obtaining an input color value and a reference color value for each of a plurality of color references, as well as a noise evaluation image having a color noise for evaluating noise reduction, the input color values and reference color values being in a non-linear color space. A plurality of color correction parameters are determined as optimized based on evaluating a fitness function in the non-linear color space. The non-linear color space can be a CIE L*a*b* color space. The fitness function can include a color correction error and a noise amplification metric so as to reduce noise amplification during color correction.