- 专利标题: Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use
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申请号: US14396956申请日: 2013-03-15
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公开(公告)号: US09745334B2公开(公告)日: 2017-08-29
- 发明人: David Spiegel , Christopher Parker
- 申请人: YALE UNIVERSITY
- 申请人地址: US CT New Haven
- 专利权人: YALE UNIVERSITY
- 当前专利权人: YALE UNIVERSITY
- 当前专利权人地址: US CT New Haven
- 代理商 Henry D. Coleman; R. Neil Sudol
- 国际申请: PCT/US2013/032044 WO 20130315
- 国际公布: WO2013/162757 WO 20131031
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H15/26 ; A61K45/06 ; A61K31/67 ; A61K31/706 ; C07D405/14 ; A61K47/48 ; A61K31/704 ; A61K31/7028 ; A61K31/7034
摘要:
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.