A method of installing and replacing a plurality of decompression panels into a sidewall assembly of an aircraft includes coupling a first decompression panel to at least one of a sidewall and a floor panel of the sidewall assembly. The method also includes inserting a tab of the first decompression panel into a slot of a second decompression panel. The slot is defined by a flange extending along a surface of the second decompression panel. The method further includes coupling the second decompression panel to at least one of a sidewall and a floor panel of the sidewall assembly.