- 专利标题： Spectro-temporal optical encoding of information using a time-gated fluorescence resonance energy transfer (FRET)
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申请号： US13911157申请日： 2013-06-06
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公开(公告)号： US09752986B2公开(公告)日： 2017-09-05
- 发明人: W. Russ Algar , Niko Hildebrandt , Alan L. Huston , Igor L. Medintz
- 申请人： W. Russ Algar , Niko Hildebrandt , Alan L. Huston , Igor L. Medintz
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary of the Navy
- 当前专利权人： The United States of America, as represented by the Secretary of the Navy
- 当前专利权人地址： US DC Washington
- 代理机构： US Naval Research Laboratory
- 代理商 Roy Roberts
- 主分类号： B82Y15/00
- IPC分类号： B82Y15/00 ; B82Y20/00 ; G01N33/542 ; G01N33/58 ; G01N21/64
摘要：
Described herein is a time-gated, two-step FRET relay effective to provide temporal transference of a prompt FRET pathway, or provide spectro-temporal encoding analytical signals and other information. A FRET relay assembly includes a long lifetime FRET donor (for example, a lanthanide complex), a semiconductor quantum dot (QD) configured as an intermediate acceptor/donor in FRET, and a fluorescent dye configured as a terminal FRET acceptor, wherein the long lifetime FRET donor has an excited state lifetime of at least one microsecond and the QD and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds.