A display panel and a driving method thereof and a display device are disclosed, and the display panel includes two sets of pixel driving circuits; and, for every two adjacent pixel columns for each primary color, an operating voltage line for one pixel column is connected to a first set of pixel driving circuits via a connection point located at a side of a pixel array where the pixels in the first row of a pixel array are located, and an operating voltage line for the other pixel column which is connected to the second set of pixel driving circuits via a connection point located at a side of the pixel array where the pixels in the last row of the pixel array are located. The display panel can ensure the uniformity of the display luminance of the whole display panel.