A method of driving a display panel includes generating corrected grayscale data utilizing a grayscale correction value of a reference pixel including m×n pixels, “m” and “n” being natural numbers greater than zero, and driving M×N pixels of the display panel based on the corrected grayscale data, “M” and “N” being natural numbers greater than zero. “M” is greater than “m” and “N” is greater than “n.”