A timing prediction circuit and method which relate to the field of circuit technologies and may be used to predict a timing margin of a to-be-predicted digital circuit, which are used to resolve a problem that a large quantity of devices are used to predict a probability that a timing error occurs in a to-be-predicted digital circuit. The timing prediction circuit includes a combinational logic circuit, a delay circuit, a sampling circuit, and a control circuit, where the sampling circuit includes N samplers, and an input end of each sampler is separately connected to an output end of the combinational logic circuit using the delay circuit, and an output end of each sampler is connected to an input end of the control circuit, where N is an integer equal, and N≧2. The present invention can be used to predict a timing margin of a to-be-predicted digital circuit.