Invention Grant
![Tetrahydropyrazolo [3,4-b] azepine derivatives and their use as allosteric modulators of metabotropic glutamate receptors](/docs/US/2017-09-19/US09765091B2/abs.jpg.600x600.jpg)
- Patent Title: Tetrahydropyrazolo [3,4-b] azepine derivatives and their use as allosteric modulators of metabotropic glutamate receptors
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Application No.: US13809581Application Date: 2011-07-11
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Publication No.: US09765091B2Publication Date: 2017-09-19
- Inventor: Christelle Bolea , Sylvain Celanire , Lam Tang , Nigel J. Liverton , Philip Jones
- Applicant: Christelle Bolea , Sylvain Celanire , Lam Tang , Nigel J. Liverton , Philip Jones
- Applicant Address: CH Geneva US NJ Rahway
- Assignee: Addex Pharma S.A.,Merck Sharp & Dohme Corp.
- Current Assignee: Addex Pharma S.A.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CH Geneva US NJ Rahway
- Agency: Law Offices of Gerard Bilotto, P.C.
- Agent Gerard Bilotto
- Priority: GB1011831.3 20100714
- International Application: PCT/US2011/001207 WO 20110711
- International Announcement: WO2012/009001 WO 20120119
- Main IPC: C07D513/12
- IPC: C07D513/12 ; A61K31/4162 ; A61K31/429 ; A61K31/55 ; A61K45/06 ; C07D513/04 ; C07D513/14 ; A61K31/433 ; A61K31/4439 ; A61K31/506 ; A61B5/00 ; A61K9/00 ; A61K9/06 ; A61K9/10 ; A61K9/20 ; A23L5/00
![Tetrahydropyrazolo [3,4-b] azepine derivatives and their use as allosteric modulators of metabotropic glutamate receptors](/abs-image/US/2017/09/19/US09765091B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
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