The present invention provides a pixel array comprising a plurality of pixel units, each of which comprises three sub-pixels in different colors, wherein, in each pixel unit, any two adjacent sub-pixels are combined into a pixel block. Compared to the prior art, the width of the sub-pixel in the present invention increases, which reduces the difficulty of the manufacturing process of the pixel array and improves product yield. The present invention further provides a driving method of the pixel array, a display panel including the pixel array, and a display device including the display panel. When driving the above pixel array with the driving method, granular sensation of the display panel including the pixel array can be reduced, and a display effect of a display panel with higher resolution in the same size can be achieved.